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Am. Chem. Soc., Angew., Chem. Commun. などの著名学術雑誌や新聞などで生体物質関連の記事や構造式を見たら「何からどう作られるのか？」と自分に問いかけよう。\n\nThis is a type-II(Cb)-categorized lecture for graduate students; Japanese-based course, with Japanese and English material\n\nI will teach advanced chemical knowledge and way-of-thinking which are applicable for current biology, according to the following learning objectives (LOs). By middle or end of this course, students will be able to…\n\nLO1: compare a variety of chemical substances which consist living things.\nSteps to achieve LO1\n1.1 Compare structures and roles of organic molecules.\n1.2 Compare structures and roles of amino acids (monomers) and proteins (polymers).\n1.3 Compare sugar-containing molecules; especially nucleic acids (i.e., DNA and RNA).\n\nLO2: comprehend how these chemical substances are organized and metabolized in living things.\nSteps to achieve LO2\n2.1 Understanding how amino acids are synthesized and metabolized.\n2.2 Understanding how sugars are synthesized and metabolized.\n2.3 Understanding how nucleic acids are synthesized and metabolized.\n2.4 Understanding how energy is created by the above metabolized compounds via citric-acid cycle ","特になし。大学院の授業なので、皆さんの貴重な研究時間をなるべく確保できるように(>授業時間内で全てが完結するよう)最大限の配慮をする。短時間で密度の濃い内容を行うので、授業時間内は集中して受講し、課題の回答に集中して欲しい。\nYou don't have to do anything outside of the class; just keep on concentrating in the class, so as to save your precious time for your lab work.","評価方法および基準:\n 毎回の授業課題の提出、および中間・期末試験(レポート形式)で総合的に評価する。これらにより、主要な生体成分の生合成・代謝経路を有機化学反応の連関として理解しているかどうかを判断し、合格の最低基準は6割の理解(=60点以上/100点満点)とする。\n 成績評価 授業課題55%, 中間試験 20%, 期末試験 25%\n合計100点満点で、60点以上を合格とする。\n\nFinal assessment:\nAnnual quiz in every week will be performed (65%/100%), in addition to mid-term (20%) and final (25%) exam. The question covers overall goal, as well as LO1-2. \n","東6号館 821号室、月曜日の2限。同時間帯に、定期的にZoomも併用してリアルタイム・双方向型のオフィスアワーを設ける。この時間に都合が付かない場合には、メールや電話により別途アポイントメントを取ること。\nEvery Monday, 10:30-11:00 at room #E6-821 + real-time Zoom meeting","学部で学んだ有機化学が基礎になります。有機化学が生命の理解に不可欠である事を学び取って欲しい。またその中から新しい機能を持った物質創成のヒント、および生体が使う反応とフラスコ内で行う反応との共通点・相違点を学び取ってほしい。 \n 炭素は炭素同士で無限に、またあらゆる元素と共有結合を形成できる。これは有機化合物には限りがなく、生物の多様性を形成するには有機分子を使うしかないということを意味している。これからの物性研究は有機化合物を避けては成り立ちません。現代の有機合成化学は「構造式を示してくれれば合成できないものはない」力量を持つ。問題は何を作るかである。そのヒントが生体システムにある。細胞膜は液晶そのものである。その液晶現象は元はと言えば細胞膜の成分の一つ, コレステロールの誘導体の奇妙な物性から見つけ出された。防弾チョッキに使われるケブラーはタンパク質のペプチド結合とおなじ、アミド結合で繋がったポリマーである。いま騒がれている生分解性ポリマーの一つに、生体成分の一つ乳酸のポリエステルポリマーがある。太陽電池は光合成で行なわれている、光による電荷分離原理を利用している。視覚の基は生体で起きているフォトクロミズムである。有機ELの原理も蛍の光と軌を一にするetc, etc・・・・。新しい扉(物性)は新しい鍵(有機化合物)でないと開きません。柔軟で多様性に富む新しい鍵は有機化合物しかあり得ないのです。そのヒントは生体に求めてみましょう。きっと何かかがある筈です。\nTake-home message: Chemical structure is everything about property !\nMost students tend to use abbreviation of DNAs and RNAs (i.e, ATGC and AUGC) without comprehending deep inside of their chemical structure; without it, using abbreviation makes no sense. For example, can you surely explain ‘Why nature has chosen T instead of U for DNA' ?! If you'll struggle to comprehend this lecture, you gotta see different side of Mother Nature from chemical structures of biological molecules.\n","This is a type-II(Cb)-categorized lecture for graduate students.",{"id":28,"name":29,"supplement":30,"parentId":31},47,"自由科目",null,37,[33],"BCHa01r",[],[36],"他",[38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67],"DNA","RNA","amino acid","co-conzyme","enzyme","lipid","metabolism","metabolite","nucleic acid","organic chemicals for life 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